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Trial shows long-term mortality for localised prostate cancer is low even if not treated with surgery

A previous shorter follow-up of the PIVOT trial found no significant difference in mortality between men who underwent surgery for localised prostate cancer and those treated with observation only.

This finding was confirmed in a longer term follow-up (up to 20 years) of the trial, which also assessed non-fatal health outcomes.

The study was recently published in the New England Journal of Medicine reported that after almost 20 years follow-up, mortality amongst men with low-risk prostate cancer was low and not significantly different between those treated with surgery and those treated with observation only.

Patient-reported outcomes of urinary incontinence and erectile/sexual dysfunction were higher amongst those undergoing surgery after 10 years but other patient-reported outcomes were not different between groups in the longer term.

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