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Unfortunately, medical research has not yet uncovered all the details of the sperm production process, so many disorders are therefore classified as ‘cause unknown’. Forty percent of men with disorders of sperm production have their condition classified as ‘cause unknown’ or ‘idiopathic’.
As medical research continues, it is likely that genetic causes of infertility will explain a large number of the sperm production disorders now classified as cause unknown. Experiments involving gene changes in mice show that disruption of gene function can result in changes to fertility. Further studies are needed to take this experimental information and look for similarities with human infertility.
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